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- B674bcd97c45b333a691d2be74008eaf9 hasDbXref "NCIT:C97936" @default.
- B674bcd97c45b333a691d2be74008eaf9 type Axiom @default.
- B674bcd97c45b333a691d2be74008eaf9 annotatedProperty comment @default.
- B674bcd97c45b333a691d2be74008eaf9 annotatedSource MAXO_0000743 @default.
- B674bcd97c45b333a691d2be74008eaf9 annotatedTarget "Sulphonylurea antidiabetic agents bind to sulfonylurea receptor type 1 (SUR1), the subunit of ATP-sensitive inwardly-rectifier potassium (IKATP) channels on the membranes of pancreatic beta cells, thereby blocking the inward current flow (influx) of positively charged K+ ions into the cell. This results in tonic membrane depolarization, and induces a calcium ion influx through voltage-sensitive calcium channels; increased intracellular calcium ion levels trigger exocytosis of insulin-containing granules. This eventually induces secretion of insulin. The IKATP channels found in pancreatic islets are complexes of four IKATP 6.2 and four SUR1 subunits. In addition, some sulfonylureas of larger molecular size may increase the sensitivity of peripheral tissues to insulin mediated through peroxisome proliferator-activated receptor gamma (PPARgamma)." @default.