Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B68241930488f8d45e5c2113b7286a252> ?p ?o ?g. }
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- B68241930488f8d45e5c2113b7286a252 NCIT_P378 "BIOCARTA" @default.
- B68241930488f8d45e5c2113b7286a252 type Axiom @default.
- B68241930488f8d45e5c2113b7286a252 annotatedProperty NCIT_P325 @default.
- B68241930488f8d45e5c2113b7286a252 annotatedSource NCIT_C39156 @default.
- B68241930488f8d45e5c2113b7286a252 annotatedTarget "Progesterone (Pg) binds to both intracellular iPR and plasma membrane-bound mPR. After binding to Pg, iPR is recruited to the membrane associated protein tyrosine kinase p60c-src, which induces activation of the MAPK signaling pathway. This results in activation of p90Rsk and the subsequent phosphorylation and inactivation of Myt1, which favors formation of the activated cell cycle complex cyclin B-Cdc2. Activation of cyclin B-Cdc2 causes breakdown of the germinal vesicle and the initiation of oocyte maturation. In contrast, binding of Pg to mPR leads to inhibition of adenylyl cyclase (AC) through activation of Gai or inhibition of Gas. This leads to a decrease in the cAMP-dependent kinase PKA, which relieves inhibition of Cdc25C and also indirectly promotes the activation of MAPK signaling. PKA also regulates the initiation of oocyte maturation through other effects that are independent of PKA activity. (This definition may be outdated - see the DesignNote.)" @default.