Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B683c89fca960effc9fb0865c13fad822> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B683c89fca960effc9fb0865c13fad822 NCIT_P378 "NCI" @default.
- B683c89fca960effc9fb0865c13fad822 type Axiom @default.
- B683c89fca960effc9fb0865c13fad822 annotatedProperty IAO_0000115 @default.
- B683c89fca960effc9fb0865c13fad822 annotatedSource NCIT_C61737 @default.
- B683c89fca960effc9fb0865c13fad822 annotatedTarget "A quinazoline with antihypertensive and antineoplastic properties. Doxazosin is an alpha-adrenergic antagonist that selectively inhibits alpha-1 adrenergic receptors. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. This agent also shows high affinity to alpha-1c adrenoceptor, the predominant functional type in the prostate, which may partially attribute to its effect in treatment of benign prostatic hyperplasia. Furthermore, doxazosin induces apoptosis in prostate cancer cells mediated through inhibition of protein kinase B (PKB)/Akt-signaling death receptor regulatory pathway." @default.