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- B694bf240115f714da01dcac3383d204d NCIT_P378 "NCI" @default.
- B694bf240115f714da01dcac3383d204d type Axiom @default.
- B694bf240115f714da01dcac3383d204d annotatedProperty IAO_0000115 @default.
- B694bf240115f714da01dcac3383d204d annotatedSource NCIT_C119623 @default.
- B694bf240115f714da01dcac3383d204d annotatedTarget "An orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. Upon oral administration, sotagliflozin binds to and blocks both SGLT1 in the gastrointestinal (GI) tract and SGLT2 in the kidneys, thereby suppressing the absorption of glucose from the GI tract and the reabsorption of glucose by the proximal tubule into the bloodstream, respectively. This decreases glucose uptake and enhances the urinary excretion of glucose, which lowers and/or normalizes blood glucose levels. SGLT1 is the primary transporter responsible for glucose absorption from the GI tract. SGLT2, a transport protein exclusively expressed in the proximal renal tubules, mediates approximately 90% of renal glucose reabsorption from tubular fluid." @default.