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- B696d0477f36a7e39588194e45042bd15 NCIT_P378 "NCI" @default.
- B696d0477f36a7e39588194e45042bd15 type Axiom @default.
- B696d0477f36a7e39588194e45042bd15 annotatedProperty IAO_0000115 @default.
- B696d0477f36a7e39588194e45042bd15 annotatedSource NCIT_C513 @default.
- B696d0477f36a7e39588194e45042bd15 annotatedTarget "A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04)" @default.