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- B69e8e6c61d7ab1c3e5a8b1248005bce0 NCIT_P378 "NCI" @default.
- B69e8e6c61d7ab1c3e5a8b1248005bce0 type Axiom @default.
- B69e8e6c61d7ab1c3e5a8b1248005bce0 annotatedProperty IAO_0000115 @default.
- B69e8e6c61d7ab1c3e5a8b1248005bce0 annotatedSource NCIT_C14083 @default.
- B69e8e6c61d7ab1c3e5a8b1248005bce0 annotatedTarget "The polymeric immunoglobulin receptor is a model system to study protein traffic in epithelial cells. This receptor travels first to the basolateral surface where it can bind polymeric IgA or IgM. The receptor is then endocytosed and delivered to endosomes. The receptor is sorted into transcytotic vesicles which are exocytosed at the apical surface. The 103 amino acid cytoplasmic domain of the receptor contains several sorting signals. The 17 residues closest to the membrane are an autonomous signal for basolateral sorting. For endocytosis there are two signals, both of which contain tyrosines. Finally, transcytosis is signaled by serine phosphorylation. (From PubMed PMID1813030 and NCI)" @default.