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- B6a201ec7bf323994f7ecdd284f1d5bd4 NCIT_P378 "BIOCARTA" @default.
- B6a201ec7bf323994f7ecdd284f1d5bd4 type Axiom @default.
- B6a201ec7bf323994f7ecdd284f1d5bd4 annotatedProperty NCIT_P325 @default.
- B6a201ec7bf323994f7ecdd284f1d5bd4 annotatedSource NCIT_C38972 @default.
- B6a201ec7bf323994f7ecdd284f1d5bd4 annotatedTarget "The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus and heterodimerizes with the transcription factor ARNT. The Ah receptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and NAD(P)H quinone oxidoreductase. The inactive form of the Ah receptor exists in the cytoplasm as a tetrameric complex composed of the ligand binding subunit, a dimer of the 90-kDa heat shock protein, and X-associated protein 2 (also referred to as AIP or ARA9). (This definition may be outdated - see the DesignNote.)" @default.