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- B6a8b1ec0a076e2f3016ab18908fbb422 NCIT_P378 "NCI" @default.
- B6a8b1ec0a076e2f3016ab18908fbb422 type Axiom @default.
- B6a8b1ec0a076e2f3016ab18908fbb422 annotatedProperty IAO_0000115 @default.
- B6a8b1ec0a076e2f3016ab18908fbb422 annotatedSource NCIT_C874 @default.
- B6a8b1ec0a076e2f3016ab18908fbb422 annotatedTarget "A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation." @default.