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- B6aab1f6ae7840d587498f6573c53bd23 NCIT_P378 "NCI" @default.
- B6aab1f6ae7840d587498f6573c53bd23 type Axiom @default.
- B6aab1f6ae7840d587498f6573c53bd23 annotatedProperty IAO_0000115 @default.
- B6aab1f6ae7840d587498f6573c53bd23 annotatedSource NCIT_C188045 @default.
- B6aab1f6ae7840d587498f6573c53bd23 annotatedTarget "An orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential antineoplastic activity. Upon administration, CDK2 inhibitor BLU-222 selectively targets, binds to and inhibits the activity of CDK2. This may lead to cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. CDK2, a serine/threonine kinase that plays an important role in the regulation of cell cycle progression and cellular proliferation, is overexpressed in certain tumor cells." @default.