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- B6b1a078ce5ec9d556747e6fc5d32f7a7 NCIT_P378 "NCI" @default.
- B6b1a078ce5ec9d556747e6fc5d32f7a7 type Axiom @default.
- B6b1a078ce5ec9d556747e6fc5d32f7a7 annotatedProperty IAO_0000115 @default.
- B6b1a078ce5ec9d556747e6fc5d32f7a7 annotatedSource NCIT_C1087 @default.
- B6b1a078ce5ec9d556747e6fc5d32f7a7 annotatedTarget "An indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death. This agent displays selectivity activity towards both hypoxic solid tumors, which exhibits higher expression of cytochrome P450 reductase, and well-oxygenated malignant cells that overexpress the bioreductive enzyme NQO1 (NAD(P)H: quinone oxidoreductase). Apaziquone may selectively sensitize hypoxic tumor cells to radiocytotoxicity." @default.