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- B6b7aa4b802acac03bab383c6ba640afe NCIT_P378 "NCI" @default.
- B6b7aa4b802acac03bab383c6ba640afe type Axiom @default.
- B6b7aa4b802acac03bab383c6ba640afe annotatedProperty IAO_0000115 @default.
- B6b7aa4b802acac03bab383c6ba640afe annotatedSource NCIT_C47476 @default.
- B6b7aa4b802acac03bab383c6ba640afe annotatedTarget "A synthetic progestogen structurally related to levonorgestrel, with progesterone hormone receptor agonistic activity, used as a contraceptive and hormone replacement agent. Upon administration, desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA causing either gene transcription or gene repression. This eventually leads to an inhibition of gonadotropin releasing hormone (GnRH) secretion from the hypothalamus and a subsequent inhibition of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. This prevents ovulation and alters the cervical mucus." @default.