Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B6b8a473ccdba7f2e8b2fea9883c8920d> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B6b8a473ccdba7f2e8b2fea9883c8920d NCIT_P378 "NCI" @default.
- B6b8a473ccdba7f2e8b2fea9883c8920d type Axiom @default.
- B6b8a473ccdba7f2e8b2fea9883c8920d annotatedProperty IAO_0000115 @default.
- B6b8a473ccdba7f2e8b2fea9883c8920d annotatedSource NCIT_C61759 @default.
- B6b8a473ccdba7f2e8b2fea9883c8920d annotatedTarget "A benzazepine derivative with vasodilatory and antihypertensive properties. Fenoldopam, a dopamine (DA) receptor agonist, binds specifically to peripheral DA1 receptors and to alpha-2 adrenoceptors with moderate affinity. However, this agent exhibits no significant affinity to DA2, other alpha adrenergic, beta adrenergic, muscarinic, or serotonergic receptors. Receptor binding modulates the transmembrane flux of ions, thereby stimulating adenylate cyclase activity, as well as the release of prolactin. This results in vasodilatation, increased renal blood flow thereby enhancing natriuresis and diuresis leading to a lowering in diastolic blood pressure." @default.