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- B6b930144b9623fb3de32d2bb5352e4da NCIT_P378 "NCI" @default.
- B6b930144b9623fb3de32d2bb5352e4da type Axiom @default.
- B6b930144b9623fb3de32d2bb5352e4da annotatedProperty IAO_0000115 @default.
- B6b930144b9623fb3de32d2bb5352e4da annotatedSource NCIT_C113334 @default.
- B6b930144b9623fb3de32d2bb5352e4da annotatedTarget "A small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone-lysine N-methyltransferase EZH2, with potential antineoplastic activity. Upon administration, histone-lysine N-methyltransferase EZH2 inhibitor GSK2816126 inhibits the activity of EZH2 and specifically prevents the methylation of histone H3 lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated with cancer pathways and results in decreased tumor cell proliferation in cancer cells that overexpress this enzyme. EZH2, which belongs to the class of histone methyltransferases (HMTs), is overexpressed or mutated in a variety of cancers and plays a key role in tumor cell proliferation." @default.