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- B6cd139b52e29edae77f5ebb8964d92f4 NCIT_P378 "NCI" @default.
- B6cd139b52e29edae77f5ebb8964d92f4 type Axiom @default.
- B6cd139b52e29edae77f5ebb8964d92f4 annotatedProperty IAO_0000115 @default.
- B6cd139b52e29edae77f5ebb8964d92f4 annotatedSource NCIT_C190204 @default.
- B6cd139b52e29edae77f5ebb8964d92f4 annotatedTarget "The sodium salt form of zifcasiran, an RNA interference (RNAi) targeting hypoxia-inducible factor 2alpha (HIF-2a), with potential antineoplastic activity. Upon administration, zifcasiran binds to and neutralizes mRNA HIF2a, thereby preventing the production of HIF2a. This may lead to an inhibition of tumor cell proliferation. HIF2a, overexpressed in certain cell types, plays a key role in proliferation, progression and metastasis of tumors." @default.