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- B6d0937e468de7d4f1be1dc8f3c8ea95b NCIT_P378 "NCI" @default.
- B6d0937e468de7d4f1be1dc8f3c8ea95b type Axiom @default.
- B6d0937e468de7d4f1be1dc8f3c8ea95b annotatedProperty IAO_0000115 @default.
- B6d0937e468de7d4f1be1dc8f3c8ea95b annotatedSource NCIT_C946 @default.
- B6d0937e468de7d4f1be1dc8f3c8ea95b annotatedTarget "The sodium salt of a semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties. In addition, pentosan polysulfate may block endothelial P-selectin and increase microvascular blood flow in sickle cell disease." @default.