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- B6d1aa1085aeb19f21897ca77c8304126 NCIT_P378 "NCI" @default.
- B6d1aa1085aeb19f21897ca77c8304126 type Axiom @default.
- B6d1aa1085aeb19f21897ca77c8304126 annotatedProperty IAO_0000115 @default.
- B6d1aa1085aeb19f21897ca77c8304126 annotatedSource NCIT_C25797 @default.
- B6d1aa1085aeb19f21897ca77c8304126 annotatedTarget "A novel sulfonamide compound with potential antineoplastic activity. Indisulam inhibits cyclin-dependent kinases (CDK), which regulate cell cycle progression and are usually over-expressed in cancerous cells. Inhibition of CDK results in G1/S phase arrest of the cell cycle, and may lead to induction of apoptosis and inhibition of tumor cell proliferation. In addition, indisulam also inhibits carbonic anhydrases (CA), especially isoforms IX and XII that are involved in aqueous humor production and are highly overexpressed in some types of cancers. Inhibition of CA IX and XII results in interference with ion exchange and pH in hypoxic tumor tissue and preventing chemoresistance to weakly basic antineoplastic agents." @default.