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- B6d827b22ada474c655fea9567b274688 NCIT_P378 "NCI" @default.
- B6d827b22ada474c655fea9567b274688 type Axiom @default.
- B6d827b22ada474c655fea9567b274688 annotatedProperty IAO_0000115 @default.
- B6d827b22ada474c655fea9567b274688 annotatedSource NCIT_C29309 @default.
- B6d827b22ada474c655fea9567b274688 annotatedTarget "A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability." @default.