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- B6dd1ddae8377e680f92c9e3f14495495 NCIT_P378 "NCI" @default.
- B6dd1ddae8377e680f92c9e3f14495495 type Axiom @default.
- B6dd1ddae8377e680f92c9e3f14495495 annotatedProperty IAO_0000115 @default.
- B6dd1ddae8377e680f92c9e3f14495495 annotatedSource NCIT_C167257 @default.
- B6dd1ddae8377e680f92c9e3f14495495 annotatedTarget "An orally bioavailable, selective, second-generation inhibitor of valosin-containing protein (VCP)/p97, with potential antineoplastic activity. Upon oral administration, p97 inhibitor CB-5339 binds to and inhibits the activity of p97. This prevents ubiquitin-dependent protein degradation and causes cellular accumulation of poly-ubiquitinated proteins. The inhibition of endoplasmic reticulum (ER)-associated protein degradation activates the ER-dependent stress response pathway, and leads to both an induction of apoptosis and the inhibition of cell proliferation in susceptible tumor cells. VCP/p97, a type II AAA+ ATPase, plays a key role in cellular protein homeostasis processes including ER-associated degradation (ERAD), chromatin associated degradation (CAD) and the DNA damage response (DDR). Its overexpression in many tumor cell types is associated with increased tumor cell proliferation and survival." @default.