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- B6e5ae65cbeb43891c0af460a1fcb155f NCIT_P378 "NCI" @default.
- B6e5ae65cbeb43891c0af460a1fcb155f type Axiom @default.
- B6e5ae65cbeb43891c0af460a1fcb155f annotatedProperty IAO_0000115 @default.
- B6e5ae65cbeb43891c0af460a1fcb155f annotatedSource NCIT_C37455 @default.
- B6e5ae65cbeb43891c0af460a1fcb155f annotatedTarget "A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions." @default.