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- B6ec637386f9c78412e90e814940d7e60 NCIT_P378 "NCI" @default.
- B6ec637386f9c78412e90e814940d7e60 type Axiom @default.
- B6ec637386f9c78412e90e814940d7e60 annotatedProperty IAO_0000115 @default.
- B6ec637386f9c78412e90e814940d7e60 annotatedSource NCIT_C65284 @default.
- B6ec637386f9c78412e90e814940d7e60 annotatedTarget "A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. Candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure." @default.