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- B6efcdcb8688c074f7f84a488be3558e8 NCIT_P378 "NCI" @default.
- B6efcdcb8688c074f7f84a488be3558e8 type Axiom @default.
- B6efcdcb8688c074f7f84a488be3558e8 annotatedProperty IAO_0000115 @default.
- B6efcdcb8688c074f7f84a488be3558e8 annotatedSource NCIT_C638 @default.
- B6efcdcb8688c074f7f84a488be3558e8 annotatedTarget "The hydrochloride salt of methadone, a synthetic opioid with analgesic activity. Similar to morphine and other morphine-like agents, methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily the mu-receptor, resulting in characteristic morphine-like effects including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. Because of the prolonged half-life of methadone compared to other morphine-like agents such as heroin, the onset of opiate withdrawal symptoms is slower, the duration of opiate withdrawal is prolonged, and opiate withdrawal symptoms are less severe." @default.