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- B6f5a524dc9dba2f676a2a8f8b73b2ac2 NCIT_P378 "NCI" @default.
- B6f5a524dc9dba2f676a2a8f8b73b2ac2 type Axiom @default.
- B6f5a524dc9dba2f676a2a8f8b73b2ac2 annotatedProperty IAO_0000115 @default.
- B6f5a524dc9dba2f676a2a8f8b73b2ac2 annotatedSource NCIT_C61668 @default.
- B6f5a524dc9dba2f676a2a8f8b73b2ac2 annotatedTarget "A semisynthetic, broad-spectrum, beta-lactamase-resistant, third-generation cephalosporin with antibacterial activity. Ceftizoxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.