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- B6f6f495e0f1557e4f46372840162b8dd NCIT_P378 "NCI" @default.
- B6f6f495e0f1557e4f46372840162b8dd type Axiom @default.
- B6f6f495e0f1557e4f46372840162b8dd annotatedProperty IAO_0000115 @default.
- B6f6f495e0f1557e4f46372840162b8dd annotatedSource NCIT_C103819 @default.
- B6f6f495e0f1557e4f46372840162b8dd annotatedTarget "The hydrochloride salt form of the quinazoline derivative erlotinib labeled with the positron-emitting isotope carbon C 11, with potential use in imaging. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic tyrosine kinase domain of the epidermal growth factor receptor (EGFR). Following exposure to this agent, EGFR expression status can be determined and EGFR overexpressing tumor cells can be visualized using positron emission tomography (PET) imaging. This may be useful in determining the tumor cell response to a particular EGFR kinase inhibitor in individual patients. EGFR, a receptor tyrosine kinase, is overexpressed in numerous cancer cell types, and plays a significant role in tumor cell progression." @default.