Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B70783e3a585aa91e3a4e4fb1d5ea82f8> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B70783e3a585aa91e3a4e4fb1d5ea82f8 NCIT_P378 "NCI" @default.
- B70783e3a585aa91e3a4e4fb1d5ea82f8 type Axiom @default.
- B70783e3a585aa91e3a4e4fb1d5ea82f8 annotatedProperty IAO_0000115 @default.
- B70783e3a585aa91e3a4e4fb1d5ea82f8 annotatedSource NCIT_C148178 @default.
- B70783e3a585aa91e3a4e4fb1d5ea82f8 annotatedTarget "A modified, replicative oncolytic vaccinia virus (VV), deleted of the genes for tyrosine kinase (TK) and ribonucleotide reductase (RR), and expressing the yeast-originated, bifunctional cytosine deaminase/uracil phosphoribosyltransferase gene (FCU1), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of the oncolytic vaccinia virus TG6002, the virus preferentially targets and infects tumor cells, causing oncolysis. In turn, the lysed tumor cells release various tumor-associated antigens (TAAs), which induce an immune response against the tumor cells. Upon concomitant administration of the non-cytotoxic prodrug flucytosine (5-fluorocytosine; 5-FC), the FCU1 expressed in the infected cancer cells produce the enzymes cytosine deaminase and uracil phosphoribosyltransferase which catalyze the conversion of 5-FC into the cytotoxic forms 5-fluorouracil (5-FU) and 5-fluoro-uridilyl monophosphate (5-FUMP); 5-FU and 5-FUMP exert a cytotoxic effect in the infected tumor cells. Double gene deletion (TK-RR-) restricts the propagation of TG6002 to the tumor cells, thereby reducing toxicity to normal cells." @default.