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- B70d5d758e02f6738f36b0e72d5b38491 NCIT_P378 "NCI" @default.
- B70d5d758e02f6738f36b0e72d5b38491 type Axiom @default.
- B70d5d758e02f6738f36b0e72d5b38491 annotatedProperty IAO_0000115 @default.
- B70d5d758e02f6738f36b0e72d5b38491 annotatedSource NCIT_C123927 @default.
- B70d5d758e02f6738f36b0e72d5b38491 annotatedTarget "A long-acting, engineered and pegylated version of human granulocyte-colony stimulating factor (G-CSF), with potential hematopoietic activity. Similar to G-CSF, pegfilgrastim anti-neutropenic factor (ANF) binds to and activates specific cell surface receptors, and stimulates neutrophil progenitor proliferation and differentiation. Therefore, this agent may prevent the duration and incidence of chemotherapy-induced neutropenia. Compared to filgrastim, the conjugation with a branched polyethylene glycol molecule reduces renal clearance and increases its plasma half-life." @default.