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- B70f606df27af015fcc95d051e913e320 NCIT_P378 "NCI" @default.
- B70f606df27af015fcc95d051e913e320 type Axiom @default.
- B70f606df27af015fcc95d051e913e320 annotatedProperty IAO_0000115 @default.
- B70f606df27af015fcc95d051e913e320 annotatedSource NCIT_C61670 @default.
- B70f606df27af015fcc95d051e913e320 annotatedTarget "A semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephapirin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.