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- B70f68895cc0f312bd6e6d7e4b6bfa7a2 NCIT_P378 "NCI" @default.
- B70f68895cc0f312bd6e6d7e4b6bfa7a2 type Axiom @default.
- B70f68895cc0f312bd6e6d7e4b6bfa7a2 annotatedProperty IAO_0000115 @default.
- B70f68895cc0f312bd6e6d7e4b6bfa7a2 annotatedSource NCIT_C180835 @default.
- B70f68895cc0f312bd6e6d7e4b6bfa7a2 annotatedTarget "An orally available inhibitor of class I, II, and III B-Raf (BRAF) protein kinases, with potential antineoplastic activity. Upon administration, exarafenib binds to and inhibits Class I, Class II, or Class III B-Raf mutations. This prevents B-Raf-mediated signal transduction pathways, which may lead to an inhibition of tumor growth in B-Raf mutant cells. B-Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway, which is often deregulated and mutated in human cancers, and plays a key role in tumor cell proliferation and survival." @default.