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- B72af122d3ec479b870045b98598e736a NCIT_P378 "KEGG" @default.
- B72af122d3ec479b870045b98598e736a type Axiom @default.
- B72af122d3ec479b870045b98598e736a annotatedProperty NCIT_P325 @default.
- B72af122d3ec479b870045b98598e736a annotatedSource NCIT_C91480 @default.
- B72af122d3ec479b870045b98598e736a annotatedTarget "Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes." @default.