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- B72d2cc13eab74bc27ee3c8f4787a713b NCIT_P378 "NCI" @default.
- B72d2cc13eab74bc27ee3c8f4787a713b type Axiom @default.
- B72d2cc13eab74bc27ee3c8f4787a713b annotatedProperty IAO_0000115 @default.
- B72d2cc13eab74bc27ee3c8f4787a713b annotatedSource NCIT_C179080 @default.
- B72d2cc13eab74bc27ee3c8f4787a713b annotatedTarget "A small-molecule inhibitor of the serine-threonine kinase Aurora B, with potential antineoplastic activity. Upon administration, defosbarasertib specifically binds to and inhibits Aurora kinase B, which disrupts spindle checkpoint functions and chromosome alignment, and results in the disruption of chromosome segregation and cytokinesis. This inhibits cell division and cell proliferation and induces apoptosis in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types." @default.