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- B72e1b87416a260181c50e0629b412f60 NCIT_P378 "NCI" @default.
- B72e1b87416a260181c50e0629b412f60 type Axiom @default.
- B72e1b87416a260181c50e0629b412f60 annotatedProperty IAO_0000115 @default.
- B72e1b87416a260181c50e0629b412f60 annotatedSource NCIT_C65229 @default.
- B72e1b87416a260181c50e0629b412f60 annotatedTarget "A semisynthetic, broad spectrum beta-lactam penicillin with antibacterial activity. Amdinocillin specifically binds to and inactivates penicillin-binding protein 2 (PBP 2) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Given the fact that most beta-lactam penicillins bind almost exclusively to PBPs 1 and 3, amdinocillin is able to synergize with other penicillins in the treatment against bacterial infections." @default.