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- B7358a98ce22974bf62ef21ea54e23a31 NCIT_P378 "NCI" @default.
- B7358a98ce22974bf62ef21ea54e23a31 type Axiom @default.
- B7358a98ce22974bf62ef21ea54e23a31 annotatedProperty IAO_0000115 @default.
- B7358a98ce22974bf62ef21ea54e23a31 annotatedSource NCIT_C76172 @default.
- B7358a98ce22974bf62ef21ea54e23a31 annotatedTarget "A semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefozopran binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.