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- B735ebcd2021a7e3374261ff0e02c059a NCIT_P378 "NCI" @default.
- B735ebcd2021a7e3374261ff0e02c059a type Axiom @default.
- B735ebcd2021a7e3374261ff0e02c059a annotatedProperty IAO_0000115 @default.
- B735ebcd2021a7e3374261ff0e02c059a annotatedSource NCIT_C29245 @default.
- B735ebcd2021a7e3374261ff0e02c059a annotatedTarget "The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone." @default.