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- B738908af523fd03cacaa8fbb48e735b0 NCIT_P378 "NCI" @default.
- B738908af523fd03cacaa8fbb48e735b0 type Axiom @default.
- B738908af523fd03cacaa8fbb48e735b0 annotatedProperty IAO_0000115 @default.
- B738908af523fd03cacaa8fbb48e735b0 annotatedSource NCIT_C154275 @default.
- B738908af523fd03cacaa8fbb48e735b0 annotatedTarget "A long-acting recombinant fusion protein composed of human serum albumin (HSA) fused to granulocyte colony stimulating factor (G-CSF), with potential granulopoietic activity. Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, thereby stimulating the proliferation, differentiation, function, and survival of neutrophil precursors and mature neutrophils. This may prevent granulocytopenia. HSA fusion increases the molecular weight of G-CSF, prolongs its half-life and masks G-CSF, thereby preventing G-CSF degradation which further increases the half-life and bioavailability of G-CSF." @default.