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- B73cdfaed37a71b200aff2c3318fd6d08 NCIT_P378 "NCI" @default.
- B73cdfaed37a71b200aff2c3318fd6d08 type Axiom @default.
- B73cdfaed37a71b200aff2c3318fd6d08 annotatedProperty IAO_0000115 @default.
- B73cdfaed37a71b200aff2c3318fd6d08 annotatedSource NCIT_C170918 @default.
- B73cdfaed37a71b200aff2c3318fd6d08 annotatedTarget "An RNA interference (RNAi) targeting hypoxia-inducible factor 2alpha (HIF-2a), with potential antineoplastic activity. Upon administration, zifcasiran binds to and neutralizes mRNA HIF2a, thereby preventing the production of HIF2a. This may lead to an inhibition of tumor cell proliferation. HIF2a, overexpressed in certain cell types, plays a key role in proliferation, progression and metastasis of tumors." @default.