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- B742398ca75847b75793787448dd0e302 NCIT_P378 "KEGG" @default.
- B742398ca75847b75793787448dd0e302 type Axiom @default.
- B742398ca75847b75793787448dd0e302 annotatedProperty NCIT_P325 @default.
- B742398ca75847b75793787448dd0e302 annotatedSource NCIT_C91495 @default.
- B742398ca75847b75793787448dd0e302 annotatedTarget "p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways." @default.