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- B74b7002e0125decf80a1b497de72f3f8 NCIT_P378 "NCI" @default.
- B74b7002e0125decf80a1b497de72f3f8 type Axiom @default.
- B74b7002e0125decf80a1b497de72f3f8 annotatedProperty IAO_0000115 @default.
- B74b7002e0125decf80a1b497de72f3f8 annotatedSource NCIT_C95737 @default.
- B74b7002e0125decf80a1b497de72f3f8 annotatedTarget "An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.