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- B752e23e266b27a63ab95b6922c6d9620 NCIT_P378 "NCI" @default.
- B752e23e266b27a63ab95b6922c6d9620 type Axiom @default.
- B752e23e266b27a63ab95b6922c6d9620 annotatedProperty IAO_0000115 @default.
- B752e23e266b27a63ab95b6922c6d9620 annotatedSource NCIT_C102783 @default.
- B752e23e266b27a63ab95b6922c6d9620 annotatedTarget "An antibody drug conjugate containing the humanized monoclonal antibody, hRS7, against tumor-associated calcium signal transducer 2 (TACSTD2 or TROP2) and linked to the active metabolite of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN-38), with potential antineoplastic activity. The antibody moiety of sacituzumab govitecan selectively binds to TROP2. After internalization and proteolytic cleavage, SN-38 selectively stabilizes topoisomerase I-DNA covalent complexes, resulting in DNA breaks that inhibit DNA replication and trigger apoptosis. TROP2, also known as epithelial glycoprotein-1 (EGP-1), is a transmembrane calcium signal transducer that is overexpressed by a variety of human epithelial carcinomas; this antigen is involved in the regulation of cell-cell adhesion and its expression is associated with increased cancer growth, aggressiveness and metastasis." @default.