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- B756cd7efba504fa02e35b0ea44c6af2c NCIT_P378 "KEGG" @default.
- B756cd7efba504fa02e35b0ea44c6af2c type Axiom @default.
- B756cd7efba504fa02e35b0ea44c6af2c annotatedProperty NCIT_P325 @default.
- B756cd7efba504fa02e35b0ea44c6af2c annotatedSource NCIT_C91811 @default.
- B756cd7efba504fa02e35b0ea44c6af2c annotatedTarget "Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetylcholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+, K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and H+ secretion into the stomach lumen." @default.