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- B75a14cacdf7cd14a49ddec8fa07807d3 NCIT_P378 "NCI" @default.
- B75a14cacdf7cd14a49ddec8fa07807d3 type Axiom @default.
- B75a14cacdf7cd14a49ddec8fa07807d3 annotatedProperty IAO_0000115 @default.
- B75a14cacdf7cd14a49ddec8fa07807d3 annotatedSource NCIT_C47620 @default.
- B75a14cacdf7cd14a49ddec8fa07807d3 annotatedTarget "The hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system." @default.