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- B762bc160a7c00ff6e3cde901e8a42bad NCIT_P378 "NCI" @default.
- B762bc160a7c00ff6e3cde901e8a42bad type Axiom @default.
- B762bc160a7c00ff6e3cde901e8a42bad annotatedProperty IAO_0000115 @default.
- B762bc160a7c00ff6e3cde901e8a42bad annotatedSource NCIT_C97660 @default.
- B762bc160a7c00ff6e3cde901e8a42bad annotatedTarget "An orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation." @default.