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- B76ccc8c7064f6f096bacfd453d1daec6 NCIT_P378 "NCI" @default.
- B76ccc8c7064f6f096bacfd453d1daec6 type Axiom @default.
- B76ccc8c7064f6f096bacfd453d1daec6 annotatedProperty IAO_0000115 @default.
- B76ccc8c7064f6f096bacfd453d1daec6 annotatedSource NCIT_C156710 @default.
- B76ccc8c7064f6f096bacfd453d1daec6 annotatedTarget "A long-acting, extended-release microsphere formulation of the acetate form of goserelin, a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH), with potential antineoplastic activity. Upon administration, goserelin binds to and activates pituitary gonadotropin-releasing hormone (GnRH) receptors. Prolonged administration of goserelin inhibits the secretion of pituitary gonadotropin, thereby decreasing levels of testosterone (in males) and estradiol (in females). Administration of this agent in an extended-release formulation may result in the regression of sex hormone-sensitive tumors and a reduction in sex organ size and function." @default.