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- B775e6120870142ab4490a2af098ccc89 NCIT_P378 "NCI" @default.
- B775e6120870142ab4490a2af098ccc89 type Axiom @default.
- B775e6120870142ab4490a2af098ccc89 annotatedProperty IAO_0000115 @default.
- B775e6120870142ab4490a2af098ccc89 annotatedSource NCIT_C1889 @default.
- B775e6120870142ab4490a2af098ccc89 annotatedTarget "A synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Accordingly, brostallicin may be effective against MMR-defective tumors that are refractory to various anticancer agents." @default.