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- B77f3ac37f5eaa5fc4cda6b76e6690623 NCIT_P378 "NCI" @default.
- B77f3ac37f5eaa5fc4cda6b76e6690623 type Axiom @default.
- B77f3ac37f5eaa5fc4cda6b76e6690623 annotatedProperty IAO_0000115 @default.
- B77f3ac37f5eaa5fc4cda6b76e6690623 annotatedSource NCIT_C2267 @default.
- B77f3ac37f5eaa5fc4cda6b76e6690623 annotatedTarget "A hormone involved in sleep regulatory activity, and a tryptophan-derived neurotransmitter, which inhibits the synthesis and secretion of other neurotransmitters such as dopamine and GABA. Melatonin is synthesized from serotonin intermediate in the pineal gland and the retina where the enzyme 5-hydroxyindole-O-methyltransferase, that catalyzes the last step of synthesis, is found. This hormone binds to and activates melatonin receptors and is involved in regulating the sleep and wake cycles. In addition, melatonin possesses antioxidative and immunoregulatory properties via regulating other neurotransmitters." @default.