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- B7861d61f43e90c3eca76890572a613b7 NCIT_P378 "NCI" @default.
- B7861d61f43e90c3eca76890572a613b7 type Axiom @default.
- B7861d61f43e90c3eca76890572a613b7 annotatedProperty IAO_0000115 @default.
- B7861d61f43e90c3eca76890572a613b7 annotatedSource NCIT_C152632 @default.
- B7861d61f43e90c3eca76890572a613b7 annotatedTarget "A proprietary synthetic oligonucleotide-based agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity. Upon administration, tilsotolimod binds to and activates TLR9 expressed by plasmacytoid dendritic cells (pDCs) and B-cells. This initiates immune signaling pathways, activates B-cells and pDCs, and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity." @default.