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- B789fdcf7f10acaed16c4176e04b66546 NCIT_P378 "NCI" @default.
- B789fdcf7f10acaed16c4176e04b66546 type Axiom @default.
- B789fdcf7f10acaed16c4176e04b66546 annotatedProperty IAO_0000115 @default.
- B789fdcf7f10acaed16c4176e04b66546 annotatedSource NCIT_C62010 @default.
- B789fdcf7f10acaed16c4176e04b66546 annotatedTarget "A semisynthetic, ergot alkaloid with antiparkinson and lactation inhibitory activities. Bromocriptine selectively binds to and activates the postsynaptic dopamine D2-like receptors in the corpus striatum of the central nervous system (CNS). D2-like receptors are coupled to inhibitory G-proteins, which inhibit adenylyl cyclase, thereby preventing signal transduction mediated via cAMP and leading to an inhibitory effect on neurotransmission. This improves Parkinson symptoms, such as dyskinesia. Bromocriptine also has an inhibitory effect on the anterior pituitary gland, which results in blockage of prolactin secretion, thereby suppressing lactation." @default.