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- B78d86bf548dd728799ae34a3731a3e66 NCIT_P378 "NCI" @default.
- B78d86bf548dd728799ae34a3731a3e66 type Axiom @default.
- B78d86bf548dd728799ae34a3731a3e66 annotatedProperty IAO_0000115 @default.
- B78d86bf548dd728799ae34a3731a3e66 annotatedSource NCIT_C102849 @default.
- B78d86bf548dd728799ae34a3731a3e66 annotatedTarget "A synthetic peptide targeting the substrates of casein kinase 2 (CK2), with potential antineoplastic activity. Upon administration and nucleolar localization, CK2-targeting synthetic peptide CIGB-300 binds to phosphoacceptor sites on the CK2 substrates, in particular the oncoprotein nucleophosmin (B23 or NPM1). This blocks the activation of B23 and induces apoptosis, thereby inhibiting tumor cell growth in susceptible tumor cells. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. Overexpression of B23 has been correlated with increased cellular growth and proliferation as well as inhibition of differentiation and apoptosis." @default.