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- B790f2129e7eb0cf44eecbd59fad12cb1 NCIT_P378 "NCI" @default.
- B790f2129e7eb0cf44eecbd59fad12cb1 type Axiom @default.
- B790f2129e7eb0cf44eecbd59fad12cb1 annotatedProperty IAO_0000115 @default.
- B790f2129e7eb0cf44eecbd59fad12cb1 annotatedSource NCIT_C20230 @default.
- B790f2129e7eb0cf44eecbd59fad12cb1 annotatedTarget "HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to 39 nM mitoxantrone, an anthracenedione antitumor agent. Subsequent exposure of the HL-60/MX1 cells to higher concentrations of mitoxantrone led to the emergence of cells capable of growth at 190 nM. HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin." @default.