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- B791ba51f434f63ca196ffa008e7fa56f NCIT_P378 "NCI" @default.
- B791ba51f434f63ca196ffa008e7fa56f type Axiom @default.
- B791ba51f434f63ca196ffa008e7fa56f annotatedProperty IAO_0000115 @default.
- B791ba51f434f63ca196ffa008e7fa56f annotatedSource NCIT_C185869 @default.
- B791ba51f434f63ca196ffa008e7fa56f annotatedTarget "A vaccine consisting of a lipid nanoparticle (LNP) encapsulating four messenger RNAs (mRNAs) encoding the Epstein-Barr Virus (EBV) envelope glycoproteins gp42, gp220, gH and gL, with potential immunizing activity against EBV. Upon intramuscular administration of LNP-encapsulated EBV mRNA vaccine mRNA-1189, the LNP binds to the plasma membrane of cells and releases the mRNAs into the cells. The mRNAs are then translated by ribosomes to produce the EBV envelope glycoproteins. This may activate both humoral and cellular immune responses which may result in protection against EBV infection. EBV, a ubiquitous human herpes virus, is associated with infectious mononucleosis and various malignancies, including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas." @default.