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- B7a24c2996e7e08a469b8dda52b1fddb8 NCIT_P378 "NCI" @default.
- B7a24c2996e7e08a469b8dda52b1fddb8 type Axiom @default.
- B7a24c2996e7e08a469b8dda52b1fddb8 annotatedProperty IAO_0000115 @default.
- B7a24c2996e7e08a469b8dda52b1fddb8 annotatedSource NCIT_C61775 @default.
- B7a24c2996e7e08a469b8dda52b1fddb8 annotatedTarget "A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens." @default.