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- B7a29f3546d13f5bf24157cc79eb7e355 NCIT_P378 "NCI" @default.
- B7a29f3546d13f5bf24157cc79eb7e355 type Axiom @default.
- B7a29f3546d13f5bf24157cc79eb7e355 annotatedProperty IAO_0000115 @default.
- B7a29f3546d13f5bf24157cc79eb7e355 annotatedSource NCIT_C84880 @default.
- B7a29f3546d13f5bf24157cc79eb7e355 annotatedTarget "A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA." @default.